Toxic and Drug-Induced Myopathies
Clues for Differential Diagnosis of Neuromuscular Disorders, Springer International Publishing Ag, ss.307-316, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/978-3-031-33924-0_17
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.307-316
- Anahtar Kelimeler: Amphiphilic drug myopathies, Antiretroviral related mitochondrial myopathy, Colchicine-related antimicrotubular myopathy, Statin myopathy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Many medications, even commonly used ones, from various branches of medicine may cause potentially reversible muscle damage. This clinical presentation is one of toxic, or drug-induced myopathy. These myopathies generally present with proximal muscle weakness, myalgia, cramps, creatinine kinase changes, and myoglobinuria caused by rhabdomyolysis. They may be confused with inflammatory myopathies because of the proximal muscle involvement in subacute stages. The pathophysiology of muscle damage in skeletal muscle has many underlying mechanisms including necrotizing, mitochondrial, inflammatory, microtubular, myofibrillar, and autophagic processes. In this chapter, all forms of toxic and drug-induced myopathies are briefly discussed. Examples of patients with their muscle biopsy images, and changes observed in muscle in toxic and drug-induced myopathies are explained. At the end of the chapter, under the title “All About the Pathology of Toxic and Drug-Induced Myopathies,” case examples, surprising cases, short clinical histories, and histopathological pictures are presented.