Novel markers of ventricular repolarization are associated with mortality in patients undergoing surgical aortic valve replacement for severe aortic stenosis
Journal of Cardiac Surgery, cilt.36, sa.12, ss.4591-4596, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 12
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/jocs.16063
- Dergi Adı: Journal of Cardiac Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.4591-4596
- Anahtar Kelimeler: aortic stenosis, aortic valve replacement, Tp-e interval, Tp-e, QT ratio, Tp-e, QTc ratio
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Aortic stenosis (AS) is the most common degenerative valvular heart disease that can affect left ventricular functions. Tp-e interval and Tp-e/QT ratio is a novel repolarization marker which is associated with adverse cardiovascular events in several cardiovascular diseases. In our study, our aim is to investigate the prognostic effect of Tp-e interval, Tp-e/QT and Tp-e/QTc ratios on mortality in patients who underwent successful surgical aortic valve replacement (AVR). Methods: A total of three hundred seventy-five patients undergoing successful surgical AVR were included in this study. Then, patients were divided into two groups according to mortality as group 1 without mortality (342 patients) and group 2 with mortality (33 patients). Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were calculated for both groups. Results: Tp-e interval (71 (63.7–77); 86 (84–88), p <.001), Tp-e/QT ratio (0.19 (0.17–0.20); 0.23 (0.22–0.23), p <.001) and Tp-e/QTc ratio (0.17 ± 0.02; 0.21 ± 0.01, p <.001) were higher in group 2 compared to group 1. In multivariate logistic regression analyses Tp-e interval (odds ratio [OR]: 1.315, 95% confidence interval [CI]: 1.203–1.437, p <.001), Tp-e/QT ratio (OR: 7.334, 95% CI: 3.274–1.643, p <.001) and Tp-e/QTc ratio (OR: 2.567, 95% CI: 4.106–1.605, p <.001) were found to be independent predictors of mortality. Additionally, a Kaplan-Meier survival analysis also revealed that long term survival was found to be significantly decreased in patients with higher Tp-e/QT ratio (Log-Rank p <.001) and Tp-e/QTc ratio (Log-Rank p <.001). Conclusion: Tp-e interval, Tp-e dispersion, Tp-e/QT, and Tp-e/QTc ratios are associated with worse prognosis after surgical AVR in patients with severe AS. All of them are also independent predictors of mortality.