Serum hepcidin, iron metabolism and infection parameters in children with anemia of inflammation and with iron deficiency anemia Demir eksikliği ve inflamasyon anemili çocuklarda serum hepsidini, demir metabolizması ve enfeksiyon parametreleri
Turkish Journal of Biochemistry, cilt.39, sa.4, ss.529-533, 2014 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2014
- Doi Numarası: 10.5505/tjb.2014.19480
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.529-533
- Anahtar Kelimeler: Anemia, ferritin, hepcidin, infection, inflammation, iron deficiency
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Hepcidin is a key regulator of iron homeostasis. Increased hepcidin concentrations cause iron sequestration in enterocytes and macrophages. The role of hepcidin in children with iron-deficiency anemia and anemia of inflammation is unclear. In this study, we aimed to evaluate the use of serum hepcidin level as an index for iron deficiency and inflammation anemia in pediatric population. Furthermore, hepcidin is also known to be an acute-phase reactant induced by interleukin-6 (IL-6) during infection. Therefore, we investigated the relationships between hepcidin and inflammatory markers. Methods: This study included 50 children with anemia (13 with iron deficiency and 37 with inflammation) and 17 age- and gender-matched healthy children (control group). Parameters related to iron metabolism (ferritin, serum iron and total iron binding capacity), infection (Creactive protein, white blood cell count and neutrophil percentage) and hepcidin levels were measured. Results: Serum hepcidin levels in patients with anemia of inflammation (362.63±132.27 ng/ mL) were significantly higher than in patients with iron-deficiency anemia (234.10±93.59 ng/ mL) and healthy controls (220.44±49.52 ng/mL) (p=0.002, p<0.001, respectively). Serum hepcidin levels were positively correlated with ferritin (r=0.246, p=0.045), leucocytes (r=0.259, p=0.034) and CRP (r=0.426, p<0.001) levels in all children. Conclusion: This study suggested that hepcidin may have the potential advantage of being able to distinguish between anemia of inflammation and iron-deficiency anemia. In addition, serum hepcidin levels are significantly correlated with acute phase reactants and can be more useful marker than CRP which decreases quickly after the onset of an infection.