Does helicobacter pylori eradication improve inflammation and lipid profile in patients with coronary artery disease?
Nobel Medicus, cilt.5, sa.3, ss.65-69, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 3
- Basım Tarihi: 2009
- Dergi Adı: Nobel Medicus
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.65-69
- Anahtar Kelimeler: Helicobacter pylori, eradication, inflammation, lipid profile
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
• Objective: We aimed to evaluate the influences of H. pylori eradication on the inflammation and the lipid profile in the H.pylori positive patients with coronary artery disease (CAD). • Material and Method: Ninety five patients were evaluated with coronary angiography initially H.pylori were tested by using urea breath test in 72 CAD patients. H. pylori an eradication therapy was applied to 30 patients with H.pylori infection for 14 days while 22 patients with H.pylori infection were not given eradication therapy. Lipid profile and high sensitive C-reactive protein levels were measured and compared in both eradicated and noneradicated groups before and two months after the H.pylori eradication. • Results: Seventy two patients had CAD and 23 patients were normal as an angiographically. Fifty two CAD (72%) patients and 15 non-CAD (65%) patients had H.pylori infection and the difference was statistically not significant. Total cholesterol, LDL-cholesterol and hs-CRP were significantly decreased in H. pylori eradication treated group (n=25) compared to non-treaked group (n=22). However, changes in HDL-cholesterol and triglyceride levels were not significant statistically. • Conclusion: Eradication of H. pylori in patients with CAD decrease total cholesterol , LDL-cholesterol and high sensitive C-reactive protein levels. This may help to slow down the atherosclerotic process indirectly in these patients.