Silent Corticotroph Pituitary Neuroendocrine Tumor: A Case Report
Duzce Medical Journal, cilt.28, sa.2, ss.252-256, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.18678/dtfd.1899708
- Dergi Adı: Duzce Medical Journal
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.252-256
- Anahtar Kelimeler: Pituitary neoplasms, cushing disease, adrenocorticotropic hormone
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Silent corticotroph pituitary neuroendocrine tumors are a rare subtype of non-functioning pituitary neuroendocrine tumors that lack the clinical and biochemical manifestations of Cushing disease. These tumors are associated with an aggressive clinical cour se because of a tendency for rapid progression and invasive growth, as well as a high recurrence rate. We present a 41-year-old woman without Cushingoid symptoms who presented with headache, bitemporal hemianopia, and diplopia. MRI revealed a mass extending into the suprasellar region, measuring approximately 2 × 4 cm, with internal necrotic areas and post-contrast enhancement. Following transsphenoidal resection, immunohistochemical staining demonstrated positivity for adrenocorticotropic hormone, confirmi ng the diagnosis of a silent corticotroph pituitary neuroendocrine tumor. This case highlights the importance of recognizing silent corticotroph pituitary neuroendocrine tumors, the treatment approach, and long-term follow-up.