Early treatment results of locally advanced (stage III) breast cancer Lokal ileri evre (evre III) meme kanserlerinde erken tedavi sonuclarimiz
Erciyes Tip Dergisi, cilt.21, sa.1, ss.47-51, 1999 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 1999
- Dergi Adı: Erciyes Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.47-51
- Anahtar Kelimeler: Breast neoplasms, Radiotherapy, Tamoxifen
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Purpose: In this retrospective study, 46 patients with locally advanced, non metastatic, non inflammatory breast cancer who were treated with postoperative radiotherapy (RT) chemotherapy (CT) ± tamoxiphene (Tmx.) were assessed in terms of overall survival and disease free survival rates. Patients and methods: The patients involved in the study were treated at Erciyes University Gevher Nesibe Hospital between 1992-1995 The median age of patients is 49 (28-74) years and the median follow-up is 26 (6-47) months. In general, the patients were treated primarily by surgery, CT and/or RT was administered after surgery (S). Systemic treatment consisted of a combination of CMF, FEC or FAC in four-six cycles. Thirteen patients were not given CT. Fifty gray RT was given to regional lymph nodes and chest wall. Results: Since the follow-up was 26 months according to Kaplan-Meier's four years' projected survival; the overall four-year survival rate was 21.86%, and four- year disease-free survival was 13.67%. In the CT and RT ± Trax. group, (33 patients), the overall four-year survival rate was 41.28 % while in 13 patients who were not green CT, this was 28 76 % (p = 0 48). In 33 patients treated with S, RT and CT ± Tmx., the four-year disease-free survival rate was 17.90%; in patients who were not given CT, this was 16.76 % (p= 0.49). Conclusion: Multimodal treatment which consisted of S, RT and CT ± Tmx was more effective in locally advanced breast cancer.