Results of interferon treatment in chronic hepatitis B Kronik B hepatitinde interferon tedavisi ile elde edilen sonuclar
Gulhane Medical Journal, cilt.42, sa.3, ss.219-224, 2000 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 3
- Basım Tarihi: 2000
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.219-224
- Anahtar Kelimeler: Chronic Hepatitis B, Interferon Therapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Data related to long-term results of interferon (IFN) therapy in chronic hepatitis B is not sufficient at present although there are lots of studies and results including short-term outcomes. In this study; results of IFN treatment obtained in the short term and at the end of different follow-up periods in patients with chronic hepatitis B in our clinics were investigated retrospectively. Overall 50 patients (28 male, mean age 32) diagnosed chronic hepatitis B and given IFN treatment were evaluated with their serologic, biochemical and histopathological findings. 25 patients were treated with IFN alpha-2a and 25 with alpha-2b (there times weekly, 5 or 9 million units) for six months. At the end of the treatment; complete response (loss of HBV-DNA in serum, normalization of ALT levels) was obtained in 29 (58 %) patients and partial response (persistence of HBV-DNA in serum, normalization of ALT levels) in 2 (4%) patients. There was no response in the remaining 19 (38%) patients. All patients were followed-up 12-42 months (mean 24 months). During the follow-up, relaps (reproduction of HBV-DNA in serum and rising in ALT levels) occurred in 13 patients. Clinical and laboratory findings of the other 18 patients (36% of all cases) were normal in the course of the follow-up. In the histopathologic evaluation of the cases with complete response, it was found that hepatocelluler inflammation evidently improved at the end of the treatment. Cirrhosis or hepatocellular carcinoma were not seen in any of these cases either while 2 unresponders died because of acute liver failure. HBs Ag didn't become negative in any case. Response rate to IFN in the treatment of chronic hepatitis B isn't in a sufficient level. However, long-term remission in association with HBV-DNA negativity can be obtained in the vast majority of the patients with response.