A case of terbinafine associated hepatic injury TERBINAFIN'E BAGLI KOLESTATIK-HEPATOSELLULER TIPDE BIR HEPATIT VAKASI
Turkish Journal of Gastroenterology, cilt.7, sa.1, ss.90-92, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 1996
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.90-92
- Anahtar Kelimeler: Drug-induced hepatitis, Hepatotoxicity, Terbinafine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this report, we describe a case of terbinafine-associated hepatic injury. The patient was treated with terbinafine 250 mg daily for onychomycosis of toenails. After one month of treatment she developed icterus and liver function abnormalities. Since extrahepatic cholestasis, viral hepatitis and primary bile duct diseases were excluded, the cause of liver function abnormalities was probably due to treatment with terbinafine. These abnormalities returned to normal which lasted for 8 weeks, except hyperbilirubinemia within 18 weeks. The hepatotoxic effect of terbinafine is probably an idiosyncratic reaction.