Association between copeptin and contrast-induced nephropathy in patients with ST-elevation myocardial infarction Associação entre a copeptina e a nefropatia induzida por contraste nos doentes com enfarte do miocárdio com elevação do segmento ST

YILDIRIM E., Cabbar A. T.

Revista Portuguesa de Cardiologia, cilt.38, sa.12, ss.873-879, 2019 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 12
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.repc.2019.06.005
  • Dergi Adı: Revista Portuguesa de Cardiologia
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.873-879
  • Anahtar Kelimeler: Contrast-induced nephropathy, Copeptin, Myocardial infarction, Percutaneous coronary intervention
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to investigate the predictive value of copeptin levels in the development of contrast-induced nephropathy (CIN). Methods: A total of 274 patients diagnosed with ST-elevation myocardial infarction (STEMI) and who had undergone primary percutaneous coronary intervention were included in the study. The patients were divided into two groups according to the presence (CIN+) or absence (CIN-) of CIN. These groups were compared in terms of demographic characteristics, laboratory findings and risk factors. Results: Copeptin levels (10.68±6.43 vs. 7.07±05.53 pmol/l; p<0.001) and peak creatinine (1.46±1.20 vs. 1.03±0.20 mg/dl; p=0.005) were significantly higher in the CIN+ group than in the CIN- group. Female gender was significantly more prevalent in the CIN- group compared to the CIN+ group (19% vs. 8.6%; p<0.05). Copeptin level at hospital admission (OR: 2.36, p=0.005) was found to be an independent predictor for CIN development. Conclusion: Copeptin level is an independent predictor of CIN development in patients with acute STEMI that can be detected rapidly and easily. This result indicates that physicians should be aware of the possibility of CIN development in patients with high copeptin levels and preventive measures should start early.