Minimally invasive extracorporeal circulation versus conventional cardiopulmonary bypass in patients undergoing cardiac surgery (MiECS): Rationale and design of a multicentre randomised trial

Anastasiadis, Kyriakos; Antonitsis, Polychronis; Papazisis, Georgios; Haidich, Bettina; Liebold, Andreas; Punjabi, Prakash; Gunaydin, Serdar; El-Essawi, Aschraf; Rao, Vivek; Serrick, Cyril; Condello, Ignazio; Nasso, Giuseppe; Bozok, Sahin; Daylan, Ahmet; Argiriadou, Helena; Deliopoulos, Apostolos; Karapanagiotidis, Georgios; Ashkanani, Fatma; Moorjani, Narain; Cale, Alex; Erdoes, Gabor; Bennett, Mark; Starinieri, Pascal; Carrel, Thierry; Murkin, John

doi:10.1177/02676591241272009

Minimally invasive extracorporeal circulation versus conventional cardiopulmonary bypass in patients undergoing cardiac surgery (MiECS): Rationale and design of a multicentre randomised trial

Anastasiadis K., Antonitsis P., Papazisis G., Haidich B., Liebold A., Punjabi P., ...Daha Fazla

Perfusion (United Kingdom), cilt.40, sa.4, ss.923-932, 2025 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 4
Basım Tarihi: 2025
Doi Numarası: 10.1177/02676591241272009
Dergi Adı: Perfusion (United Kingdom)
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
Sayfa Sayıları: ss.923-932
Anahtar Kelimeler: minimal invasive, extracorporeal circulation, cardiopulmonary bypass, cardiac surgery
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Introduction: The ultimate answer to the question whether minimal invasive extracorporeal circulation (MiECC) represents the optimal perfusion technique in contemporary clinical practice remains elusive. The present study is a real-world study that focuses on specific perfusion-related clinical outcomes after cardiac surgery that could potentially be favourably affected by MiECC and thereby influence the future clinical practice. Methods: The MiECS study is an international, multi-centre, two-arm randomized controlled trial. Patients undergoing elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or combined procedure (CABG + AVR) using extracorporeal circulation will be randomized to MiECC or contemporary conventional cardiopulmonary bypass (cCPB). Use of optimized conventional circuits as controls is acceptable. The study design includes a range of features to prevent bias and is registered at clinicaltrials.gov (NCT05487612). Results: The primary outcome is a composite of postoperative serious adverse events that could be related to perfusion technique occurring up to 30 days postoperatively. Secondary outcomes include use of blood products, ICU and hospital length of stay (30 days) as well as health-related quality of life (30 and 90 days). Conclusions: The MiECS trial has been designed to overcome perceived limitation of previous trials of MiECC. Results of the proposed study could affect current perfusion practice towards advancement of patient care.