Standardized uptake value and metabolic tumor volume measured by 18F FDG PET/CT are sensitive biomarkers for the presence of lymph node metastasis in patients with cervical carcinoma
Revista Espanola de Medicina Nuclear e Imagen Molecular, cilt.33, sa.5, ss.268-273, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 5
- Basım Tarihi: 2014
- Doi Numarası: 10.1016/j.remn.2013.05.007
- Dergi Adı: Revista Espanola de Medicina Nuclear e Imagen Molecular
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.268-273
- Anahtar Kelimeler: Cervical cancer, FDG PET/CT, Lymphatic involvement, SUVmax, Metabolic tumor volume
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The aim of this study was to evaluate whether tumor standardized uptake value (SUVmax) and metabolic tumor volume (MTV) associate with the presence of PET-positive pelvic/para-aortic lymph nodes (LN) in cervical cancer patients. Method: Seventy-four patients with stage IB-IVB cervical cancer (squamous [n:66], nonsquamous [n:8]), who were referred to FDG-PET/CT department for initial staging, were enrolled in this study. Results: Patients were staged according to International Federation of Gynecology and Obstetrics [FIGO] criteria as; stage I (n:5), stage II (n:25), stage III (n:15) and stage IV (n:29). PET/CT detected 53 patients with hypermetabolic LN (average SUVmax: 7.5±4.1, range: 4.1-22.8, pelvic LN: 29 patients, para-aortic LN:5 patients, pelvic and para-aortic LN:19 patients). SUVmax and MTV were significantly higher in patients with PET-positive LN compared to others (18.4 and 88.8cm3 vs. 13.9 and 39.9cm3 respectively, p=0.007 for SUVmax, p=0.0001 for MTV). Cut-off values in association with PET-positive LN were 15.2 for SUVmax and 35cm3 for MTV on ROC curve analysis. There was no correlation between SUVmax and MTV (correlation coefficient (R2)=0.07). MTV differed significantly with FIGO stages (41, 98 and 107cm3, in stage II, III and IV respectively, p=0.015). Conclusion: Presence of PET-positive LN correlates with tumor SUVmax and MTV of cervical tumor. These findings support the use of PET/CT in the pretreatment evaluation of cervical cancer patients in order to identify cases with high risk of lymphatic involvement. © 2013 Elsevier España, S.L.U. and SEMNIM.