Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer
Nuclear Medicine Communications, cilt.43, sa.10, ss.1084-1091, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 10
- Basım Tarihi: 2022
- Doi Numarası: 10.1097/mnm.0000000000001607
- Dergi Adı: Nuclear Medicine Communications
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.1084-1091
- Anahtar Kelimeler: F-18- FDG, Ga-68-FAPI-04, NSCLC, PET, CT, SUVmax
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim In this study, we aimed to compare the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) and Gallium-68 labeled fibroblast activator protein inhibitor (68Ga-FAPI)-04 PET/CT in the tumor-node-metastasis (TNM) staging of patients with nonsmall cell lung cancer (NSCLC) and investigate whether adenocarcinoma (ADC) and squamous cell cancer (SCC) exhibit different uptake patterns on 68Ga-FAPI-04 PET/CT. Materials and method Twenty-nine patients with a histopathologically-confirmed diagnosis of NSCLC, who had no history of previous radiation therapy or chemotherapy and underwent 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT imaging between January 2021 and December 2021 were included in this retrospective study. Staging was performed using the 8th edition of the TNM staging system on both 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT images. Standardized uptake value (SUV)maxand tumor-to-background ratios (TBR) were calculated on primary lesions and metastases. Results There was no statistically significant difference in primary lesions in terms of SUVmaxand TBR values. However, 68Ga-FAPI-04 PET/CT was significantly superior to 18F-FDG PET/CT in terms of the number of lymph nodes and bone metastases revealed. The SUVmaxand TBR values of lymph nodes, hepatic lesions and bone lesions were significantly higher on 68Ga-FAPI-04 PET/CT than on 18F-FDG PET/CT. 68Ga-FAPI-04 PET/CT changed the disease stage of three patients (10.9%). The diagnostic accuracy of 68Ga-FAPI-04 PET/CT was 100%, whereas the diagnostic accuracy of 18F-FDG PET/CT was 89.6% (P = 0.250). Conclusion Although 68Ga-FAPI-04 PET/CT detected more lesions and higher diagnostic accuracy than 18F-FDG PET/CT in NSCLC, neither method was statistically superior to each other in terms of diagnostic accuracy in TNM staging.