Does base excess predict kidney injury in neonates with hypoxic-ischemic encephalopathy?

KANMAZ KUTMAN, Hayriye; KADIOĞLU ŞİMŞEK, Gülsüm; SİYAH BİLGİN, Betül; AKIN, Mustafa; CANPOLAT, Fuat

doi:10.1016/j.earlhumdev.2023.105911

Does base excess predict kidney injury in neonates with hypoxic-ischemic encephalopathy?

KANMAZ KUTMAN H. G., KADIOĞLU ŞİMŞEK G., SİYAH BİLGİN B., AKIN M., CANPOLAT F. E.

Early Human Development, cilt.188, 2024 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 188
Basım Tarihi: 2024
Doi Numarası: 10.1016/j.earlhumdev.2023.105911
Dergi Adı: Early Human Development
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Hypoxic-ischemic encephalopathy, Base excess, Kidney failure, Olyguria, Acute kidney injury
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

In neonates with hypoxic-ischemic encephalopathy (HIE), we studied the correlation between cord blood base excess (BE) and kidney function. Among 225 infants, 29 % had oliguria. BE levels differed significantly between oliguric and non-oliguric infants (p < 0.01), with a negative correlation to kidney injury (r = −0.544, p < 0.01). BE < −18 had 85 % specificity and 76 % sensitivity in predicting kidney injury (AUC = 0.88). These findings suggest BE as a valuable indicator of impending kidney injury in HIE infants, though underlying mechanisms may vary.