Enigma of COVID-19: is “multisystem inflammatory syndrome in adults” (MIS-A) predictable?
BMC Infectious Diseases, cilt.22, sa.1, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 1
- Basım Tarihi: 2022
- Doi Numarası: 10.1186/s12879-022-07303-8
- Dergi Adı: BMC Infectious Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
- Anahtar Kelimeler: COVID-19, Multisystem inflammatory syndrome in adults (MIS-a), Mortality, Prognosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A. Methods: The data of 2333 patients were retrospectively analyzed. Results: MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity. Conclusions: Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.