A novel marker for predicting type 1 retinopathy of prematurity: C-reactive protein/albumin ratio
International Ophthalmology, cilt.43, sa.9, ss.3345-3353, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 9
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/s10792-023-02740-z
- Dergi Adı: International Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE
- Sayfa Sayıları: ss.3345-3353
- Anahtar Kelimeler: Retinopathy of prematurity, C-reactive protein, Albumin, CRP-to-albumin ratio, Neutrophil, Lymphocyte
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: We aimed to investigate whether the C-reactive protein (CRP) to albumin ratio (CAR) an inflammatory predictor can be used as a marker for the development of ROP. Methods: Gestational age, birth weight, gender, neonatal, and maternal risk factors were recorded. The patients were divided into two groups: those who did not develop ROP (ROP −) and those who developed ROP (ROP +). The ROP + group was further separated into two groups: those who required treatment (ROP + T) and those who were not treated (ROP + NT). The following parameters were noted in the first postnatal week and at the end of the first postnatal month: CRP, albumin, CAR, white blood cell (WBC), neutrophil, lymphocyte, neutrophil-to-lymphocyte ratio (NLR), distribution red cell width (RDW), platelet (Plt), and RDW/platelet ratio. Results: We evaluated 131 premature infants who met the inclusion criteria. There was no difference between the main groups in hemogram parameters and CAR at the postnatal first week. WBC count (p = 0.011), neutrophil count (p = 0.002), and NLR were high (p = 0.004) in the ROP + group at the end of the postnatal 1st month. The CAR level at the end of the first month was higher in the ROP + group (p = 0.027). CAR was similar between the ROP + T and ROP + NT groups (p = 0.112) in the postnatal first week but higher in the treatment-required group at the end of the first month (p < 0.01). Conclusion: High CAR and high NLR at the end of the postnatal first month can be used to predict the development of severe ROP.