The effects of methylene blue on adhesion formation in a rat model of experimental peritonitis Deneysel peritonit modelinde metilen mavisinin adezyon formasyonu üzerine etkileri
Ulusal Travma ve Acil Cerrahi Dergisi, cilt.17, sa.3, ss.205-209, 2011 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.5505/tjtes.2011.93609
- Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.205-209
- Anahtar Kelimeler: Adhesion, methylene blue, peritonitis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND We investigated the effects of methylene blue (MB) on the early and late phases of adhesion and abscess formation in a standard colonic wall injury and fecal peritonitis model in rats. METHODS There were four groups: Group I (only laparotomy, n=10), Group II (peritonitis + MB, n=15), Group III (peritonitis + saline, n=15), and Group IV (colon incision + saline, n=15). Mortality, morbidity, adhesion scores, histopathologic analyses, serum tumor necrosis factor-alpha (TNF-α) levels, and tissue hydroxyproline (5-HP) levels were evaluated in all animals. Descriptive statistical methods were used with Kruskal-Wallis test. When a statistical difference was obtained between groups, Mann-Whitney U test was used to confirm the difference between two groups. RESULTS Adhesion scores of Groups I, III and IV were significantly higher than in Group II. TNF-α levels were significantly higher in Groups I, III and IV. 5-HP levels were significantly lower in Groups I and II compared to Groups III and IV. CONCLUSION Based on these results, it appears that MB may prevent peritoneal adhesions in a peritonitis model, but wound healing could be impaired. MB should be further evaluated because of its dual effect.