Impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes: A retrospective analysis in patients with tympanic membrane perforation due to chronic otitis media
Journal of Laryngology and Otology, cilt.133, sa.12, ss.1068-1073, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 133 Sayı: 12
- Basım Tarihi: 2019
- Doi Numarası: 10.1017/s0022215119002391
- Dergi Adı: Journal of Laryngology and Otology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1068-1073
- Anahtar Kelimeler: Otitis Media, Tympanic Membrane Perforation, Tympanoplasty, Fascia Graft, Platelet-Rich Fibrin, Graft Survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective To evaluate the impact of platelet-rich fibrin therapy in tympanoplasty type 1 surgery on graft survival and frequency-specific hearing outcomes.Methods Patients who underwent tympanoplasty type 1 surgery were randomised into temporal fascia graft alone (n = 55) and temporal fascia graft plus platelet-rich fibrin therapy (n = 36) groups. Graft survival and hearing outcomes were recorded.Results Graft survival rates were significantly higher in the temporal fascia graft plus platelet-rich fibrin therapy group than in the temporal fascia graft alone group at one (100.0 vs 85.5 per cent, p = 0.020), three (97.2 vs 80.0 per cent, p = 0.024) and six months post-operatively (94.4 vs 74.5 per cent, p = 0.031). The difference in hearing gain between groups was not significant.Conclusion Our findings revealed that the use of a platelet-rich fibrin plus temporal fascia graft for type 1 tympanoplasty was associated with more favourable post-operative outcomes than the use of temporal fascia alone, both in terms of tympanic membrane healing and graft survival; hearing restoration outcomes were similar.