Clozapine in treatment-resistant schizophrenia: Followed-up study for three years Tedaviye dirençli şizofrenide klozapin: Üç yillik i̇zlem
Klinik Psikofarmakoloji Bulteni, cilt.10, sa.2, ss.74-80, 2000 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 2
- Basım Tarihi: 2000
- Dergi Adı: Klinik Psikofarmakoloji Bulteni
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.74-80
- Anahtar Kelimeler: Clozapine, Three years follow-up, Treatment-resistant schizophrenia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Object: In this open trial the efficacy and safety of clozapine in treatment-resistant schizophrenic patients were investigated. Method: Treatment-resistant 29 schizophrenic patients were followed-up for three years. Drug efficacy was assessed by means of the BPRS, SAPS, and SANS. Side effects were rated with UKU side effect scale, EEG, biochemical and hormone analysis. Results and Conclusion: At the end of 3rd year we found a decrease of 41.1% in BPRS score, %49.0 in SAPS score, and %33.6 in SANS score compared with pretreatment scores. The most common side effects were weight gain, hypersalivation, sedation, and EEG abnormalities. The agranulocytosis, which was reported as the most significant side effect, was not observed in this study group.