Clinical insight into hypercalcemia in children


Creative Commons License

KORKMAZ H. A.

Endokrynologia Polska, cilt.76, sa.4, ss.374-384, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 76 Sayı: 4
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5603/ep.105609
  • Dergi Adı: Endokrynologia Polska
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.374-384
  • Anahtar Kelimeler: calcium, phosphorus, hypercalcemia, parathyroid hormone, 25-hydroxyvitamin D, hyperparathyroidism
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Plasma calcium levels are regulated by many factors, including the levels of calcium-sensitive receptors, parathyroid hormone, parathyroid hormone receptors, vitamin D, vitamin D receptors, and other proteins. Plasma calcium is also related to genetic structure; albumin, creatinine, and phosphorus levels; and blood pH. Multiple factors affect hypercalcemia in children, making its management challenging. These factors have led to accurate diagnosis for mostly mild and moderate cases of hypercalcemia, resulting in a management dilemma. In many clinics, physicians face undiagnosed cases of hypercalcemia even if the hypercalcemia algorithms are followed accurately. In this narrative review, we discuss a logical approach to the investigation and subsequent clinical management of hypercalcemia in children.