Antioxidative, cytotoxic, and antibacterial properties of self-assembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film Antioksidacijska, citotoksična i antibakterijska svojstva samoslozivih glicinsko-histidinskih dipeptida sa srebrnim nanočesticama i bez njih u bioinspiriranom filmu
Arhiv za Higijenu Rada i Toksikologiju, cilt.73, sa.2, ss.169-177, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 73 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.2478/aiht-2022-73-3658
- Dergi Adı: Arhiv za Higijenu Rada i Toksikologiju
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, Greenfile, MEDLINE, Pollution Abstracts, SportDiscus, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.169-177
- Anahtar Kelimeler: Ag, antibacterial surface, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, toxicity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Recent years have seen much attention being given to self-assembly of dipeptide-based structures, especially to self-regulation of dipeptide structures with different amino acid sequences. In this study we investigated the effects of varying solvent environments on the self-assembly of glycine-histidine (Gly-His) dipeptide structures. First we determined the morphological properties of Gly-His films formed in different solvent environments with scanning electron microscopy and then structural properties with Fourier-transform infrared (FTIR) spectroscopy. In addition, we studied the effects of Gly-His films on silver nanoparticle (AgNP) formation and the antioxidant and cytotoxic properties of AgNPs obtained in this way. We also, assessed antibacterial activities of Gly-His films against Gram-negative Escherichia coli and Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus. Silver nanoparticle-decorated Gly-His films were not significantly cytotoxic at concentrations below 2 mg/mL but had antibacterial activity. We therefore believe that AgNP-decorated Gly-His films at concentrations below 2 mg/mL can be used safely against bacteria.