Lymphocytic hypophysitis: An underestimated disease affecting the sellar region Limfocytarne zapalenie przysadki: Zbyt rzadko rozpoznawana choroba okolicy siodła tureckiego
Neurologia i Neurochirurgia Polska, cilt.45, sa.2, ss.174-179, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 2
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/s0028-3843(14)60030-x
- Dergi Adı: Neurologia i Neurochirurgia Polska
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.174-179
- Anahtar Kelimeler: Lymphocytic hypophysitis, Neuropathology, Pituitary adenoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Hypophysitis is an inflammation of the pituitary gland and includes a heterogeneous group of diseases presenting with impaired pituitary gland function. Hundreds of cases have been reported after Goudie and Pinkerton's initial report on a young postpartum woman who died after progressive lymphocytic infiltration of the adenohypophysis in 1962. A 17-year-old woman presented with a three-year history of headache, galactorrhoea and excessive weight gain. The patient had used oral contraceptives for several years until one year previously. Her examination demonstrated only bilateral heteronymous hemianopsia. Laboratory investigation revealed elevated prolactin and decreased gonadotropin levels. Magnetic resonance imaging showed a sellar mass with suprasellar extension. Surgical removal of the lesion was performed via a transsphenoidal approach. A diagnosis of lymphocytic hypophysitis was confirmed by histopathological evaluation. Hypophysitis is an underestimated disease affecting the pituitary gland. Cases are usually diagnosed as adenomas and treated with surgical removal. This case is presented due to the extremely rare infiltration of the pituitary gland by predominantly lymphocytes.