The growth characteristics of patients with Noonan syndrome: Results of three years of growth hormone treatment: A nationwide multicenter study
JCRPE Journal of Clinical Research in Pediatric Endocrinology, cilt.8, sa.3, ss.305-312, 2016 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 3
- Basım Tarihi: 2016
- Doi Numarası: 10.4274/jcrpe.3013
- Dergi Adı: JCRPE Journal of Clinical Research in Pediatric Endocrinology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.305-312
- Anahtar Kelimeler: Noonan syndrome, growth hormone treatment, growth
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Noonan syndrome (NS) is a multisystem disorder, and short stature is its most striking manifestation. Optimal growth hormone (GH) treatment for NS is still controversial. In this study, using a nationwide registration system, we aimed to evaluate the growth characteristics and the clinical features of NS patients in Turkey and their growth response to GH treatment. Methods: Children and adolescents with a diagnosis of NS were included inthe study. Laboratory assessment including standard GH stimulation test results were evaluated. Height increment of patients with or without GH treatment were analyzed after three years of therapy.