THROMBOCYTOPENIA AS A RISK FACTOR FOR RETINOPATHY OF PREMATURITY
Retina, cilt.39, sa.4, ss.706-711, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.1097/iae.0000000000002028
- Dergi Adı: Retina
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.706-711
- Anahtar Kelimeler: infant, neonate, newborn, preterm, retinopathy of prematurity, thrombocytopenia, angiogenesis, neovascularization
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose:To study the association between thrombocytopenia and retinopathy of prematurity (ROP).Methods:The case-control study was conducted on preterm newborns with ROP between January 2011 and January 2014, retrospectively. The patients were assigned into two groups: Cases required intervention and controls developed no or Stage I ROP.Results:Eighty-one premature infants with Type I ROP were enrolled to the study with a mean gestational age of 27.6 ± 2.1 (range: 24-32) weeks and birth weight of 993 ± 292 (range: 560-1,930) g. Mean follow-up time was 38.3 ± 2.7 weeks (min: 32 and max: 46 weeks). Cases were individually matched to a set of controls (1:1 ratio). Thrombocytopenia (<150.000/mm3) was seen in 58 (71.6%) of the cases with Type I ROP, whereas only 17 (21%) of the controls had thrombocytopenia (P < 0.001). Logistic regression analysis showed that bronchopulmonary dysplasia and thrombocytopenia were significantly associated with Type I ROP (relative risk [95% confidence interval]: 4.19 [1.47-12] and 6.69 [2.83-15.9], respectively). The thrombocytopenia ratio (P = 0.073), thrombocytopenia 1 week before intervention (P = 0.076) and platelet transfusion ratio (P = 0.062) tended to be higher in Zone I ROP compared with Zone II ROP.Conclusion:In our study, there was a significant association between thrombocytopenia and Type I ROP.