Gynecology for metastatic colorectal cancer
Colon Polyps and Colorectal Cancer: Second Edition, Springer International Publishing Ag, ss.723-732, 2020
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2020
- Doi Numarası: 10.1007/978-3-030-57273-0_36
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.723-732
- Anahtar Kelimeler: Cancer, Colon, Over, Rectum, Uterus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Genitourinary system is not an unusual site for a metastasis. Colorectal carcinomas (CRC) metastasize usually to ovaries and rarely to the uterus, cervix, and vagina. CRC with synchronous ovarian metastasis are often discovered at the time of surgery as an ovarian cancer by a gynecological oncologist, and these tumors constitute approximately 2-5% of ovarian carcinomas. Also it has been reported that 2% of the patients with primary CRC develop metachronous ovarian metastases within 2 years after the primary resection of CRC. Both synchronous and metachronous ovarian metastases originating from CRC are usually bilateral, multiloculated, cystic, and around 100 mm lesions. Sign and symptoms of them are non-specific; as abdominopelvic pain and increased abdominal girth are the main symptoms, they are mainly operated by gynecologic oncologist because metastatic ovarian tumor mass usually is bigger than CRC tumor size. Using CA 125/CEA ratio appears to be more valuable than CEA alone for differentiation between patients with ovarian cancer and ovarian metastasis of CRC. CA 125/CEA ratio with a value below 25 and bilaterally of tumors strongly indicates ovarian metastases from gastrointestinal tumors. Aggressive resection for ovarian metastases from primary CRCs is associated with good overall survival (OS). The main prognostic factor is R0 resection of the tumor.