INTERACTION OF STAPHYLOCOCCUS AUREUS WITH SOLID LIPID NANOPARTICLES STAPHYLOCOCCUS AUREUS'UN KATI LİPİD NANOPARTİKÜLLER İLE ETKİLEŞİMİ
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.46, sa.2, ss.322-329, 2022 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.33483/jfpau.1063296
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.322-329
- Anahtar Kelimeler: Bacterial uptake, flow cytometry, solid lipid nanoparticle, Staphylococcus aureus
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The ability of bacteria to develop resistance to existing antibiotics has made the search for new antimicrobials or antimicrobial formulations a matter of urgency. Among drug delivery systems, solid lipid nanoparticles are considered solution-oriented systems with advantages for targeted drug delivery. Material and Method: In this study, the bacterial uptake of SLNs encapsulated with fluorescein into Staphylococcus aureus ATCC 29213 was investigated by a flow cytometry method to be a preliminary study for antibiotic improvement studies. Result and Discussion: It was determined that ~60% of fluorescein-SLNs were taken into S. aureus ATCC 29213 cells within 1h. The results were found to be promising for future studies with antibiotics.