Gamma-glutamyltransferase activity in patients with calcific aortic stenosis
Turk Kardiyoloji Dernegi Arsivi, cilt.34, sa.5, ss.288-291, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 5
- Basım Tarihi: 2006
- Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.288-291
- Anahtar Kelimeler: Aortic valve stenosis/blood, calcinosis/complications, coronary arteriosclerosis, gamma-glutamyltransferase
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: We evaluated gamma-glutamyltransferase (GGT) activity in patients with calcific aortic stenosis (AS) and investigated the association between GGT levels and the maximum and mean aortic gradients. Study design: The study included 34 patients (5 women, 29 men; mean age 63±13 years) with calcific AS. Thirty-eight subjects (8 women, 30 men; mean age 57±10 years) with echocardiographically normal aortic valves constituted the control group. Echocardiographic evaluation was performed in all the subjects and venous blood samples were obtained to determine plasma glucose, fibrinogen, total cholesterol, LDL and HDL cholesterol, triglyceride, and GGT levels. The activity of GGT was determined by the kinetic method. Associations were sought between GGT levels and the maximum and mean aortic gradients. Results: In the AS group, the mean maximum and mean gradients of the aortic valve were 74±15 mmHg and 39±9 mmHg, respectively. Fibrinogen concentrations differed significantly between the patient and control groups (3.9±1.7 mg/dl and 2.9±0.9 mg/dl, respectively; p<0.02). Activity of GGT was not influenced by gender in both groups (p>0.05). Compared to controls (21±14 U/l), the mean GGT level was significantly high-er in the AS group (39±13 U/l; p=0.005). In linear regression analysis, weak but significant sex- and age-adjusted correlations were found between the GGT level and the maximum (r=0.20, p<0.001) and mean (r=0.17, p<0.001) aortic gradients. Conclusion: Patients with calcific AS have higher GGT levels compared to controls, suggesting the presence of a common etiologic mechanism for both calcific AS and coronary artery disease.