Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients
Journal of Cosmetic Dermatology, cilt.19, sa.11, ss.3032-3037, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 11
- Basım Tarihi: 2020
- Doi Numarası: 10.1111/jocd.13367
- Dergi Adı: Journal of Cosmetic Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
- Sayfa Sayıları: ss.3032-3037
- Anahtar Kelimeler: choroidal thickness, optical coherence tomography, retinal nerve fiber layer, retinal pigment epithelium, vitiligo
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Vitiligo is one of the common pigmentary disorders affecting the ocular structures. Aim: To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes. Methods: The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. All of the participants underwent detailed eye examinations and spectral-domain optical coherence tomography (SD-OCT) examinations. CT was measured manually with enhanced depth imaging optical coherence tomography (Edi-OCT) (subfoveal [SubF], nasal n500 µm [N1], n1500 µm [N2]), and temporal (t500 µm [T1], t1500 µm [T2]). Results: In vitiligo patients, CT values were significantly lower in the SubF, N1, N2, T1, and T2 areas compared to the control group (P =.001, P =.011, P =.002, P =.005, P ˂.001, respectively). Periorbital involvement did not affect CT (P =.355, P =.746, P =.443, P =.633, P =.558, respectively). However, in patients with periorbital region involvement, the CT was significantly reduced if the lesion had a universal character (P ˂.001, P =.001, P =.011, P ˂.001, P =.002, respectively). It was observed that RPE thickness decreased in vitiligo, but this difference was not statistically significant (P =.140). RNFL thickness was unaffected in all quadrants. A positive correlation (r =.286, r =.280, respectively) was observed between the Vitiligo Area Severity Index (VASI) and age and disease duration. A negative correlation (r = −.360, r = −.316, r = −.315, r = −.313, respectively) was found in the CT of the SubF, N1, N2, T1, and T2 areas. Conclusion: Vitiligo patients should be closely monitored for possible posterior ocular segment disorders.