Evaluation of long-term results of stromal dystrophies treated with penetrating keratoplasty and deep anterior lamellar keratoplasty
Expert Review of Ophthalmology, cilt.20, sa.3, ss.149-157, 2025 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 20 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/17469899.2025.2472751
- Dergi Adı: Expert Review of Ophthalmology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Chemical Abstracts Core, CINAHL, EMBASE
- Sayfa Sayıları: ss.149-157
- Anahtar Kelimeler: Deep anterior lamellar keratoplasty, penetrating keratoplasty, stromal dystrophies
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Stromal corneal dystrophies can cause significant visual impairment, often requiring surgical intervention. This study evaluates the long-term outcomes of patients treated with penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK), focusing on visual acuity, endothelial cell density (ECD), recurrence, and complications. Research design and methods: This retrospective study included 111 eyes from 72 patients with lattice, granular, and macular corneal dystrophies treated with PK or DALK. Patients were followed up for 10 years, and best-corrected visual acuity (BCVA), ECD, and recurrence rates were analyzed. Comparisons were made between the PK and DALK groups. Results: At 1 and 10 years post-surgery, BCVA declined significantly in all groups (p < 0.05). The DALK group showed better ECD preservation compared to PK. The recurrence rates were similar between the groups, though DALK demonstrated a lower rate of endothelial cell loss and fewer complications, such as cataract and glaucoma. Conclusions: DALK offers advantages in preserving ECD and reducing long-term complications compared to PK. However, both techniques yield comparable visual outcomes. The choice of surgical approach should be individualized based on patient characteristics and dystrophy type.