Differential expression of immune system-related components in midtrimester amniotic fluid from singleton and twin pregnancies
American Journal of Obstetrics and Gynecology, cilt.193, sa.3 SUPPL., ss.942-946, 2005 (Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 193 Sayı: 3 SUPPL.
- Basım Tarihi: 2005
- Doi Numarası: 10.1016/j.ajog.2005.05.081
- Dergi Adı: American Journal of Obstetrics and Gynecology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.942-946
- Anahtar Kelimeler: twins, amniotic fluid, midtrimester, preterm premature rupture of membranes, cytokines
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: We investigated differences between singleton and twin gestations in immune mediators in midtrimester amniotic fluid. Study design: Amniotic fluid from 252 singleton and 46 twin gestations were tested by enzyme-linked immunosorbent assay for interleukin-1β, interleukin-1 receptor antagonist, interleukin-4, tumor necrosis factor-α, nitric oxide, Clara cell protein 16, leptin, and the 70-kDa heat shock protein. A subset of amniotic fluid was also tested for leukemia inhibitory factor, angiogenin, and migration inhibitory factor-related protein 8 and migration inhibitory factor-related protein 14. Data were analyzed by the Mann-Whitney U test and Spearman rank correlation. Results: Median concentrations of interleukin-1β, tumor necrosis factor-α, interleukin-4, Clara cell protein 16, leptin, and angiogenin were increased in amniotic fluid from twins; median levels of the 70-kDa heat shock protein, leukemia inhibitory factor, migration inhibitory factor-related protein 8, and migration inhibitory factor-related protein 14 were highest in amniotic fluid from singletons (P<.001). Conclusion: Elevated levels of immune activators may contribute to the increased rate of preterm premature rupture of membranes and spontaneous preterm birth in twin populations. © 2005 Mosby, Inc. All rights reserved.