Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19

Beghi, Ettore; Helbok, Raimund; Ozturk, Serefnur; KARADAŞ, Ömer; Lisnic, Vitalie; Grosu, Oxana; Kovács, Tibor; Dobronyi, Levente; Bereczki, Daniel; Cotelli, Maria; Turla, Marinella; Davidescu, Eugenia; Popescu, Bogdan; Valzania, Franco; Cavallieri, Francesco; Ulmer, Hanno; Maia, Luis; Amodt, Anne; Armon, Carmel; Brola, Waldemer; Victoria, Gryb; Riahi, Anis; Krehan, Ingomar; von Oertzen, Tim; Azab, Mohammed; Crean, Michael; Lolich, Maria; Lima, Maria; Sellner, Johann; Perneczky, Julian; Jenkins, Tom; Meoni, Sara; Bianchi, Elisa; Moro, Elena; Bassetti, Claudio; Ural, Onur; Kara, Iskender; Ozturk, Bilgin; Gavriliuc, Mihail; Odainic, Olesea; Civelli, Patrizia; Bianchi, Marta; Bunea, Teodora; Sandu, Georgiana; Toschi, Giulia; Oliveira, Vanessa; Dias, Alexandre; Jung, Simon; Hoepner, Robert; Boldingh, Marion; Agajany, Netta; Wolfson, Sharon; Michał, Lipowski; Marjiana, Lesiv; Derbali, Hajer; Seabra, Mafalda; Carvalho, Vanessa; Flemmen, Heidi; Yasuda, Clarissa; Taba, Pille; Yassin, Osama; Kiteva-Trenchevska, Gordana

doi:10.1111/ene.15293

Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19

Beghi E., Helbok R., Ozturk S., KARADAŞ Ö., Lisnic V., Grosu O., ...Daha Fazla

European Journal of Neurology, cilt.29, sa.6, ss.1663-1684, 2022 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 6
Basım Tarihi: 2022
Doi Numarası: 10.1111/ene.15293
Dergi Adı: European Journal of Neurology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo
Sayfa Sayıları: ss.1663-1684
Anahtar Kelimeler: COVID-19, neurological disorders, outcome, predictors, SARS-CoV-2
Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background and purpose: Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short- and long-term outcome of the disease. Methods: This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro-covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as ‘stable/improved’ if the modified Rankin Scale score was equal to or lower than the pre-morbid score, ‘worse’ if the score was higher than the pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months. Results: From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up. Conclusions: Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.