Is vitamin D level associated with the natural course of atopic dermatitis?
Allergologia et Immunopathologia, cilt.46, sa.6, ss.546-551, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 6
- Basım Tarihi: 2018
- Doi Numarası: 10.1016/j.aller.2017.12.004
- Dergi Adı: Allergologia et Immunopathologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.546-551
- Anahtar Kelimeler: Atopic dermatitis, Child, Vitamin D, Severity, Natural course
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Introduction and objectives: Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. Apart from its well-known role on calcium metabolism, vitamin D is reported to affect skin functions. The study aims were to: compare the vitamin D levels of children with AD and healthy children; investigate the relationship between the severity of AD and vitamin D levels; and investigate the effect of vitamin D on the natural course of AD. Patients or materials and methods: Sixty-nine patients with AD were enrolled. Seventy healthy children were assigned as control group. Clinical and demographic features of groups were recorded. The skin prick test, eosinophil counts, immunoglobulin (Ig) E levels and serum 25 OH cholecalciferol (25OHD3) levels were measured. After at least 4 years of follow-up, patients were re-evaluated for natural course of AD. Results: Mean 25OHD3 level was lower in patient group vs. control group; 19.86 ± 6.7 ng/mL (min–max: 6.8–40) vs. 24.07 ± 9.08 ng/mL, respectively, (p = 0.002). Mean 25OHD3 levels, and vitamin D status were significantly different between AD severity groups. (p < 0.05). In terms of vitamin D status in the pairwise comparison, vitamin D deficiency was greater in children with severe and moderate AD groups (respectively, p = 0.005, p = 0.018). In Tukey's post hoc analysis for 25OHD3 level, the 25OHD3 levels of severe AD are significantly lower than mild or moderate AD (respectively, p = 0.001, p = 0.026). There was a negative correlation between 25OHD3 levels and severity of AD (r = −0.480; p = 0.001). In patients reassessed after 4 years: age, the age of AD onset, vitamin D deficiency, SCORAD level and severe AD were higher in the persistent group vs. remission group, 25OHD3 levels were higher in the remission group vs. persistent group (p < 0.05). Conclusions: Mean vitamin D levels were lower in patients with AD. A negative correlation between vitamin D levels and disease severity was documented. Vitamin D may affect the natural course of atopic dermatitis. There is a need for more comprehensive studies in this regard.