Clarithromycin targeting to lung: Optimization of the size, morphology and release characteristics of albumin microspheres
Acta Poloniae Pharmaceutica - Drug Research, cilt.57, sa.5, ss.375-380, 2000 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 5
- Basım Tarihi: 2000
- Dergi Adı: Acta Poloniae Pharmaceutica - Drug Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.375-380
- Anahtar Kelimeler: Bovine serum albumin, Clarithromycin, Emulsion polymerization technique, Human serum albumin, Microspheres
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Micropheres are drug carrier system which ensures controlled release in the shape of solid sphere particles with variable diameter distributions from a few microns to a milimeter of size. The active substance is dispersed in molecular level or in forms of macroscopic particles. Clarithromycin was selected as the model active substance in our study. Clarithromycin microspheres were prepared and evaluated by an emulsion polymerization technique. Two matrix materials have been considered as the basis in preparing the selected model active substance. Natural human serum albumin and bovine serum albumin, which were frequently used in early microsphere studies and are being used in some studies as microsphere matrix material were used. Albumin microspheres containing clarithromycin were prepared by heat stabilization at different stirring rate. In the first part of our study, drug content, payload, particle size, surface morphology and release characteristics from microspheres prepared.