Defibrotide-Responsive Cutaneous Endothelial Injury Following Allogeneic Hematopoietic Stem Cell Transplant: A Case Report
Experimental and Clinical Transplantation, cilt.24, sa.4, ss.356-358, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.6002/ect.2026.0003
- Dergi Adı: Experimental and Clinical Transplantation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO)
- Sayfa Sayıları: ss.356-358
- Anahtar Kelimeler: Allogeneic hematopoietic stem cell transplantation, Leukemia, Sinusoidal obstruction syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
A 57-year-old woman with relapsed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia developed diffuse nonblanching erythematous skin lesions following allogeneic hematopoietic stem cell transplant. The lesions appeared concomitantly with hepatic sinusoidal obstruction syndrome and persisted despite engraftment and supportive therapy. Skin biopsy excluded graft-versus-host disease. Upon initiation of defibrotide for moderate hepatic sinusoidal obstruction syndrome, both hepatic and cutaneous findings resolved completely. This case underscores the systemic endothelial-protective potential of defibrotide, extending beyond the hepatic microvasculature, and highlights cutaneous endotheliopathy as a possible manifestation of transplant-associated endothelial injury.