DYNAMIC THIOL/DISULFIDE HOMEOSTASIS AND OXIDANT STATUS IN PATIENTS WITH HYPOPARATHYROIDISM DINAMI^KA TIOL/DISULFIDNA HOMEOSTAZA I OKSIDACIONI STATUS KOD PACIJENATA SA HIPOPARATIROIDIZMOM
Journal of Medical Biochemistry, cilt.39, sa.2, ss.231-239, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.2478/jomb-2019-0036
- Dergi Adı: Journal of Medical Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.231-239
- Anahtar Kelimeler: hypoparathyroidism, total oxidant status, total antioxidant status, disulfide, thiol, paraoxonase
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels. Methods: 55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples. Results: In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated. Conclusions: Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.