Retinoic acid and intestinal wound healing in intra-operatively irradiated rat
Acta Chirurgica Belgica, cilt.106, sa.1, ss.73-76, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 106 Sayı: 1
- Basım Tarihi: 2006
- Doi Numarası: 10.1080/00015458.2006.11679838
- Dergi Adı: Acta Chirurgica Belgica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.73-76
- Anahtar Kelimeler: Intestinal elongation, Intra-operative irradiation, Retinoic acid, Tensile strength, Wound healing
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: This study was undertaken to assess the effect of intra-operative radiotherapy on intestinal wound healing and prevention of its side effects by retinoic acid. Materials and methods: Thirty Spraque-Dawley rats were divided into 3 groups of (n = 10). All the groups had laparatomies and terminal ileum exteriorization. Group I was the control group with no irradiation and no anastomosis; group II had both irradiation and anastomosis and group III rats had peroral retinoic acid conditioning and irradiation + anastomosis. On the seventh postoperative day, tensile strength and intestinal elongation measurements were to evaluate the effect of retinoic acid on wound healing. Results: Compared to the non-retinoic acid conditioned group, the retinoic acid conditioned group had statistically significant higher tensile strength and lower intestinal elongation values, revealing better wound healing. Conclusion: Peroral retinoic acid supplement administration has a preventive effect on radiation-induced wound-healing inhibition in intra-operative abdominopelvic irradiation and anastomoses.