Naproxen sodium-induced toxic epidermal necrolysis: A case report and review of the literature
European Surgery - Acta Chirurgica Austriaca, cilt.37, sa.6, ss.343-347, 2005 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 37 Sayı: 6
- Basım Tarihi: 2005
- Doi Numarası: 10.1007/s10353-005-0194-8
- Dergi Adı: European Surgery - Acta Chirurgica Austriaca
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.343-347
- Anahtar Kelimeler: Adverse drug reactions, Lyell syndrome, Naproxen sodium, Toxic epidermal necrolysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Toxic epidermal necrolysis (TEN) syndrome is an uncommon, acute, life-threatening disorder that involves sloughing of skin at the dermal-epidermal junction with associated mucositis. Methods: We report a 71-year-old woman suffering from TEN. Result: Our patient suffered from TEN due to naproxen sodium (two doses, 550 mg each). After two days she was admitted to the emergency department of our hospital with a high temperature, irresistible itching, and extended maculopapular erythematous rash over the trunk. The mucous membranes of the eyes, mouth, and genitalia also showed marked inflammation; most prominent were large erosions in the genitalia area. Conclusions: With early recognition of the disease, transfer to a burn center, proper wound management, and infection monitoring, patients with TEN have an excellent chance of survival without scarring and sequelae. © Springer-Verlag 2005.