Role of cyclooxygenase 2 and endothelial nitric oxide synthetase in preclinical atherosclerosis
Fetal and Pediatric Pathology, cilt.31, sa.6, ss.432-438, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 6
- Basım Tarihi: 2012
- Doi Numarası: 10.3109/15513815.2012.659408
- Dergi Adı: Fetal and Pediatric Pathology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.432-438
- Anahtar Kelimeler: cigarette smoke, atherosclerosis, cyclooxygenase-2, eNOS
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Cyclooxygenase-2 and endothelial nitric oxide (NO) synthase enzymes may have a role in developing preclinical atherosclerosis. Designed groups were as follows: smoke exposed rats before and during pregnancy, only before pregnancy, and controls. Cross-sectional samples of abdominal aorta were examined immunohistochemically. Cyclooxygenase-2 and eNOS expression was evaluated semi-quantitatively through staining extent (focal, diffuse) and staining intensity. Diffuse COX-2 expression was detected in study groups. Endothelial NO synthase expression was diffuse in study groups. COX-2 and eNOS may contribute to the formation of preatherosclerotic lesions in offspring of rats exposed to cigarette smoke through inflammatory response. Copyright © Informa Healthcare USA, Inc.