Risk Factors for Ocular Complications and Visual Loss in Patients with Juvenile Idiopathic Arthritis-associated Uveitis at a Turkish Tertiary Ophthalmology and Pediatric Rheumatology Referral Center
Ocular Immunology and Inflammation, cilt.31, sa.10, ss.1984-1991, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31 Sayı: 10
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/09273948.2022.2123833
- Dergi Adı: Ocular Immunology and Inflammation
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.1984-1991
- Anahtar Kelimeler: Anti-TNF agents, juvenile idiopathic arthirits, ocular complication, uveitis, visual acuity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To investigate the rates of ocular complications and visual loss and their risk factors in patients with juvenile idiopathic arthritis (JIA) -associated uveitis Methods: Medical records of 51 patients were reviewed. Results: The incidence of visual loss to the 20/50 or worse was found to be 0026/ eye-year (EY) in the present study. Cataract and ocular hypertension occurred during the follow-up period and were significantly associated with visual acuity loss to 20/50 or worse (p =.008, HR 11.932, 95% CI 1.915–74.355; p =.03, HR 7.323, 95% CI 1.216–44.110, respectively). Anti-TNF therapy was initiated in 88.2% of our cases and 93.3% of them achieved uveitis inactivity. Conclusion: The risk of vision loss is higher in patients with JIA-associated uveitis who had complications at presentation. We attribute the lower complication rates and better visual outcomes in our study to the early and frequent use of biologic agents.