Evaluation of neutrophil/lymphocyte and platelet/lymphocyte ratio in patients with primary sjögren’s syndrome Primer sjögren sendromu hastalarında nötrofil/lenfosit ve trombosit/lenfosit oranlarının değerlendirilmesi
Turkiye Klinikleri Journal of Medical Sciences, cilt.40, sa.3, ss.313-319, 2020 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 3
- Basım Tarihi: 2020
- Doi Numarası: 10.5336/medsci.2019-70999
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.313-319
- Anahtar Kelimeler: Disease activity, Inflammation, Neutrophil lymphocyte ratio, Platelet-lymphocyte ratio, Sjögren's syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Sjögren's syndrome (SjS) is a chronic autoimmune disease characterized by focal lymphocytic infiltration of the exocrine glands and developed by environmental factors on the basis of genetic predisposition. The aim of this study was to determine the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values in the pSS patients and to investigate their association with disease activity. Material and Methods: 55 patients with primary Sjögren’s syndrome (pSS) and 45 healthy controls followed in rheumatology outpatient clinic of Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital were included in this study. Demo-graphic characteristics and laboratory data were retrospectively recorded. Results: No difference was determined between the groups in terms of age and gender. The PLR values were found to be statis-tically significantly higher in the pSS group compared to the healthy controls [162.53±84.49 (65.71-484), 128.04±34.63 (63.68-198.46) re-spectively] (p=0.032). NLR values were found similar in pSS and healthys [2.42±2.33 (0.67-17.40), 2.0±0.65 (0.97-3.62) respectively] (p=0.843). The level of NLR and PLR values were similar in active and inactive pSS patients. Correlation analysis showed a positive correlation between PLR levels and ESR levels (r=0.341, p=0.011). Con-clusion: PLR levels are significantly elevated in pSS patients compared to healthy controls. Also, it was shown that PLR value cor-related positively with ESR. PLR might be a useful inflammatory marker to, predict disease activity in pSS.