Intrathecal baclofen therapy in patients with traumatic spinal cord injury Travmatik spinal kord yaralanmali{dotless} hastalarda i̇ntratekal baklofen tedavisi
Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, cilt.59, sa.4, ss.281-285, 2013 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 4
- Basım Tarihi: 2013
- Doi Numarası: 10.4274/tftr.90582
- Dergi Adı: Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.281-285
- Anahtar Kelimeler: Intrathecal baclofen pump, spasticity, spinal cord injury
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To evaluate the results of intrathehal baclofen (ITB) therapy in 15 patients with traumatic spinal cord injury (SCI). Materials and Methods: Medical records of 15 patients with SCI receiving ITB were evaluated retrospectively. Degree of spasticity before and after ITB, time interval between SCI and ITB, follow-up period after ITB, first effective dose of baclofen, current dose of baclofen and the complications after ITB were obtained. Results: Eight (53%) patients had tetraplegia and seven (47%) patients had paraplegia. The mean follow-up period after ITB was 57.43±36.89 months. According to the modified Ashworth scale (MAS) mean spasticities were 3.47±0.51 before ITB and 1.50±0.51 after ITB. The difference between the mean degree of spasticity before and after ITB was significant (p=0.001). The mean first effective dose of baclofen was 174.33±92.25 μg/d. The mean current dose of baclofen was 240.42±125.19 μg/d. The differences in the mean first baclofen doses and current baclofen doses were significant between complete and incomplete patients (p=0.012; p=0.018, respectively). Complications developed in nine (60%) patients. Conclusion: ITB is an effective treatment in traumatic SCI patients with severe spasticity, however, some medical and pump system complications might develop. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing.