Assessment of complete blood count and systemic inflammatory indices in small for gestational age preterm newborns
Kuwait Medical Journal, cilt.57, sa.4, ss.234-241, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 4
- Basım Tarihi: 2025
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.234-241
- Anahtar Kelimeler: infant, premature, small for gestational age, systemic inflammatory indices, infant, premature, small for gestational age, systemic inflammatory indices
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: Scarce data exist about the complete blood count of preterm newborns with small for gestational age (SGA). It is not known how SGA affects systemic inflammatory indices in preterm infants. The aim of our study was to compare the levels of six systemic inflammatory indices in preterm infants with SGA and appropriate for gestational age (AGA). Design: A retrospective cohort study Setting: A tertiary neonatal intensive care unit Subjects: Data of preterm infants <32 weeks of gestational age were evaluated. Interventions: No intervention was performed. Main outcome measures: Six systemic inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune ratio inflammation index (SII), pan immune inflammation value (PIV), and systemic inflammation response index (SIRI) values, were calculated from the results obtained from the complete blood count. Demographical features and clinical outcomes, complete blood count and systemic inflammatory indices were compared between the AGA and SGA groups. Results: 895 infants were included in the study: 103 preterm infants with SGA and 792 preterm infants with AGA. There was no difference between the groups regarding leukocyte, monocyte, lymphocyte count, MLR and SIRI values (P>0.05). Neutrophil, platelet count, NLR, PLR, PIV and SII values were significantly lower in SGA infants than in AGA infants (P=0.001, P<0.001, P<0.001, P<0.001, P=0.016 and P<0.001, respectively). Conclusions: We found that NLR, PLR, PIV and SII values were lower in SGA preterm infants than those in AGA preterm infants. Additional studies are required to evaluate the clinical significance of these values.