Plasma Polyunsaturated Fatty Acids After Weight Loss Surgery
Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes and Adverse Effects, Elsevier, ss.529-534, 2017
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/b978-0-12-804011-9.00058-3
- Yayınevi: Elsevier
- Sayfa Sayıları: ss.529-534
- Anahtar Kelimeler: Bariatric surgery, Dyslipidemia, Inflammation, Insulin, Polyunsaturated fatty acids
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Obesity has reached epidemic proportions in the European population. Medical conditions such as insulin resistance, dyslipidemia, and hepatic steatosis are associated with obesity. Bariatric surgery is the main surgical treatment for obesity, and leads to improvement in comorbid conditions. However, impaired absorption of important nutrients and food restriction in the postoperative period after bariatric surgery can cause changes in circulating and tissue levels of polyunsaturated fatty acids (PUFAs). Omega-6 (. n-6) and omega-3 (. n-3) PUFAs are precursors of bioactive lipid mediators known as eicosanoids, and thus play an important role in inflammation and many physiological functions. The improvement of insulin action following bariatric surgery, and a significant reduction in insulin resistance, can lead to conversion of essential fatty acids to longer-chain PUFAs. This review focuses on the postoperative effects of bariatric surgery on plasma n-3 and n-6 PUFA levels, and summarizes studies that have investigated changes in PUFA levels following weight loss surgery.