Can Temporal Muscle Thickness Be a New Prognostic Factor for De Novo Glioblastoma? Temporal Kas Kalınlığı Yeni Tanı Glioblastoma için Prognostik Faktör Olabilir mi?
Medical Journal of Bakirkoy, cilt.18, sa.3, ss.303-309, 2022 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.4274/bmj.galenos.2022.2022.4-15
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE
- Sayfa Sayıları: ss.303-309
- Anahtar Kelimeler: Glioblastoma, prognosis, sarcopenia, temporal muscle
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Glioblastoma multiforme (GBM) is the most aggressive and commonly seen primary malignant brain tumor in adults. In addition to clinical, molecular and histopathological prognostic factors, sarcopenia, defined as low skeletal muscle mass, has become one of the important parameters. The relationship between skeletal muscle mass and temporal muscle thickness (TMT) has been demonstrated. We evaluated the prognostic value of TMT in patients with newly diagnosed GBM. Methods: A total of 66 GBM patients were included in this retrospective study. Left and right TMT’s from pre-operative magnetic resonance images were measured separately by an experienced radiologist, and the mean TMT value for each patient was calculated. The survival times and rates were examined with the Kaplan-Meier method. Overall survival (OS) was calculated from the day of diagnosis. The correlation coefficients and their significance were calculated using the Spearman test. Results: The median right TMT was 4.4 (1.7-9.5) mm, the left TMT was 4.1 (1.5-9.6) mm. The median TMT was 4.38 (1.66-9.45) mm. Spearman correlation test revealed a slight correlation between the mean TMT value and the age at the diagnosis (p=0.044). Spearman correlation test for gender also showed a slight correlation between the mean TMT value and gender (p=0.024). In the multivariate analysis using the Cox regression model showed that increased TMT was a positive prognostic marker for OS in GBM patients (p=0.030). Conclusion: TMT greater than 4.38 mm was found to be an independent prognostic factor in de novo glioblastoma. However, studies with larger series are needed to generalize this result to the Turkish population.