Monocyte chemoattractant protein-1 in acute coronary syndromes: Complex vicious interaction
International Journal of Cardiology, cilt.136, sa.3, ss.356-357, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 136 Sayı: 3
- Basım Tarihi: 2009
- Doi Numarası: 10.1016/j.ijcard.2008.04.080
- Dergi Adı: International Journal of Cardiology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.356-357
- Anahtar Kelimeler: Monocyte chemoattractant protein-1, Cytokine, Acute coronary syndromes
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Monocyte chemoattractant protein-1 (MCP-1) plays a crucial role both in the initiation and progression of atherosclerosis. MCP-1 is a unique cytokine produced by macrophages, smooth muscle cells and endothelial cells within atherosclerotic plaques and seems to be a reliable indicator of atherosclerotic plaque burden. Higher levels of MCP-1 have been associated with a poor prognosis and increased risk for death independent of other risk factors in patients with acute coronary syndromes. In this paper, we discussed the role of MCP-1 in the pathogenesis of acute coronary syndromes. © 2008 Elsevier Ireland Ltd. All rights reserved.