Inflammatory mediators and posterior segment involvement in ocular Behçet disease
European Journal of Ophthalmology, cilt.19, sa.6, ss.998-1003, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 6
- Basım Tarihi: 2009
- Doi Numarası: 10.1177/112067210901900616
- Dergi Adı: European Journal of Ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.998-1003
- Anahtar Kelimeler: Behcet disease, Inflammatory mediators, Posterior segment, Uveitis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose. To assess the serum level of mediators and their relation with posterior ocular involvement in patients with Behçet disease (BD). Methods. This study was a prospective, institutional clinical trial including 43 patients with ocular BD. Patients were divided into two subgroups: those with active posterior segment involvement (Group A) and those with inactive ocular BD (Group B). Group A included patients with posterior uveitis (vitritis or chorioretinal involvement), while Group B included patients with no active intraocular inflammation within the last 3 months. Serum levels of interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor (VEGF), and malondialdehyde (MDA) were measured by sandwich enzyme-linked immunosorbent assay and spectrophotometric assay and compared among the groups by independent sample t test and Mann-Whitney U-test. Results. Serum levels of the mediators in Group A (IL-6 [23.1 pg/mL], IL-8 [161.1 pg/mL], TNF-α [30.5 pg/mL], VEGF [455.9 pg/mL], MDA [10.7 μm]) were found to be significantly higher than those in Group B (IL-6 [12.2 pg/mL], IL-8 [48.4 pg/mL], TNF-α [18.6 pg/mL], VEGF [138.0 pg/mL], MDA [5.1 μm]). Conclusions. This study demonstrated that increased serum levels of inflammatory mediators including IL-6, IL-8, TNF-α, VEGF, and MDA were possibly involved in the development of posterior uveitis in BD. © Wichtig Editore, 2009.