Non-alcoholic fatty pancreas disease is associated with increased epicardial adipose tissue and aortic intima-media thickness
Acta Cardiologica Sinica, cilt.35, sa.2, ss.118-125, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.6515/acs.201903_35(2).20181009a
- Dergi Adı: Acta Cardiologica Sinica
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.118-125
- Anahtar Kelimeler: Atherosclerosis, Epicardial adipose tissue, Intinna-media thickness, Non-alcoholic fatty pancreatic disease
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: We aimed to investigate whether non-alcoholic fatty pancreas disease (NAFPD) is associated with epicardial adipose tissue (EAT), which is a kind of ectopic fat accumulation, and aortic intima-media thickness (aIMT), which is associated with subclinical atherosclerosis. Methods: Fifty-four patients with NAFPD (22 men; mean age: 52 ± 10 years) and 49 without NAFPD (16 men; mean age: 49 ± 8 years) were included in this study. NAFPD and aIMT were evaluated using transabdominal ultrasonography (TUS). EAT was evaluated with transthoracic echocardiography. Results: EAT (6.09 ± 1.52 mm and 3.87 ± 1.31 mm, p < 0.001) and aIMT [1.12 (0.60-1.90) mm vs. 0.93 (0.50-1.44) mm, p < 0.001] were significantly higher in the NAFPD positive subjects, compared to the NAFPD negative subjects. Multivariate analysis showed that age (p = 0.016), body mass index (p = 0.004), and presence of NAFPD (p = 0.024) were associated with increased aIMT. In addition, multivariate analysis demonstrated that the presence of NAFPD (p < 0.001) was associated with increased EAT. Conclusions: The presence of NAFPD on TUS is associated with increased aIMT and EAT. Our study results may suggest that NAFPD may reflect subclinical atherosclerosis and may be a simple warning sign for physicians.