Prostate-specific antigen and its derivatives in spinal cord injured patients; a case-control study Spinal kord yaralanmalı hastalarda, prostat-spesifik antijen ve türevleri: Bir vaka-kontrol çalışması
Journal of Clinical and Analytical Medicine, cilt.4, sa.6, 2013 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 6
- Basım Tarihi: 2013
- Doi Numarası: 10.4328/jcam.1108
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Spinal Cord, Prostate, Prostate-Specific Antigen
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To evaluate the effects of motor-complete spinal cord injury (SCI) on prostate volume (Vp), total prostate specific antigen (PSA), free PSA (fPSA), free-total PSA ratio (f/tPSA) and PSA density (PSAD). Material and Method: 25 SCI patients and 32 age--matched outpatient able--bodied controls were included in the analysis. Vp was measured on transrectal ultrasound, PSA, fPSA, FSH, LH and total and free testosterone levels were obtained and f/ tPSA and PSAD were calculated for all patients. Results: Mean patient age was 44.26±6.9 years. Mean Vp of the SCI group was significantly lower than controls (19.30±6.88 vs 26.96±8.79, p=0.001) while mean serum PSA, FSH, LH, total and free testosterone of the two groups were similar (p>0.05). Mean fPSA and f/tPSA were significantly lower (0.16±0.096 vs 0.28±0.18, p<0.001 and 0.20±0.18 vs 0.28±0.13, p=0.002, respectively) and PSAD was higher (0.056±0.027 vs 0.043±0.035, p=0.014) than those of the controls. Discussion: According to our findings, motor-complete SCI causes lower Vp, fPSA and f/tPSA than the controls, independent from pituitary-gonadal axis and serum testosterone without any significant impact on serum PSA. Our results regarding fPSA and PSAD need further confirmation.