Patients Admitted To Our Center With Methanol Poisoning: Retrospective Analysis
Eastern Journal of Medicine, cilt.28, sa.1, ss.46-51, 2023 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2023
- Doi Numarası: 10.5505/ejm.2023.75983
- Dergi Adı: Eastern Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.46-51
- Anahtar Kelimeler: Fomepizole, hemodialysis, metabolic acidosis, Methanol poisoning
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Methanol poisoning is caused by the production of toxic metabolites by the alcohol dehydrog enase enzyme;metabolic acidosis is a serious condition that can lead to life-threatening complications such as kidney failure, blindness, and death.In our study, it was aimed to examine the methanol poisoning cases admitted to the hospital terms of mortali ty and morbidity. Following the approval of the Ethics Committee(03/12/2019,Number: 1497),16 patients were retrospectively analyzed.The patients were divided into 2 groups as Group I(Survivor,n=11)and Group II(Nonsurvivor,n=5)and possible risk factors for mortality were examined. No statistically significant difference was found in terms of mortality,age,gender,GCS at admission,HR,MAP,urea,creatinine, and GFR values(p>0.05).In patients with nonsurvivor;In terms of pH values;A statistically significant increase was found at the12thhr compared to the 1sthr(p=0.046).It was determined that the 1st hr PaCO2 were lower than Group I.(p=0.020).No significant difference was found in terms of HCO3 values at 1.,3 .,6.,12.,24. and 48.hr according to mortality(p>0.05).In Group I;the increase in HCO3 values at the 12thhr compared to the 1st hr was found to be statistically significant(p=0.046).The methanol level was measured in 6 patients(5-249mg/dl).Ophthalmological findings were detected in 62%of the patients.The blood sugar of Group II was 132.8mg/dl(95-210)and the Group I was 216mg/dl(70-395).Hemodialysis was performed in 56.3%of the cases from the time of diagnosis.The total mortality rate is31.2%. On admission to the hospital due to methanol intoxication; here is no relationship between methanol blood level at admission and mortality but coma, GCS<7,seizures and metabolic acidosis(pH<6.9)are prognostic factors for fatal and permanent sequelae. Hemodialysis is considered the key element in the treatment of methanol intoxication..