Unpredicted effects of ankaferd® on cartilage tissue
International Journal of Clinical and Experimental Medicine, cilt.8, sa.1, ss.922-927, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 2015
- Dergi Adı: International Journal of Clinical and Experimental Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.922-927
- Anahtar Kelimeler: Ankaferd, hemostatic agent, cartilage
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper ® (ABS) into the auricular cartilage. Materials and methods: Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days. Results: The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compared to the controls. Conclusion: Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage.