EFFECT OF HYPERBARIC OXYGEN THERAPY ON FASTING BLOOD GLUCOSE AND INSULIN RESISTANCE HIPERBARIK OKSIJEN TEDAVISININ AÇLIK KAN SEKERI VE INSÜLIN DIRENCI ÜZERINDEKI ETKISI
Istanbul Tip Fakultesi Dergisi, cilt.87, sa.4, ss.327-333, 2024 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 87 Sayı: 4
- Basım Tarihi: 2024
- Doi Numarası: 10.26650/iuitfd.1488854
- Dergi Adı: Istanbul Tip Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.327-333
- Anahtar Kelimeler: Blood sugar level, diabetes mellitus, hyperbaric oxygen therapy, insulin resistance
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The subject of this study was to investigate the effect of hyperbaric oxygen (HBO2) therapy on fasting blood glucose levels and insulin resistance. The study investigated whether HBO2 therapy is effective in reducing peripheral insulin resistance in patients with and without Diabetes Mellitus (DM). Material and Methods: The study included 27 patients with and without DM who received hyperbaric oxygen therapy at a pressure of 2.4 ATA for 120 min per session with 5 min breaks in between three 25-minute O2 periods, one session per day, five days a week, for 20 sessions. Patients were divided into two groups: those without DM and those with DM. Fifteen patients did not have DM while 12 patients had DM Type 2. Glucose, C-Reactive protein (CRP), HbA1c, C-peptide, and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) values were compared at the beginning and end of treatment. Results: In repeated measurements, there was a statistically significant decrease in the mean fasting blood glucose levels in patients with DM. Patients without DM also showed a reduction in the mean fasting blood glucose levels in repeated measurements, but this decrease was not statistically significant. There was a statistically significant decrease in the mean C-pep level in repeated measurements in patients with DM and the mean insulin level in repeated measurements in patients without DM. There was a statistically significant decrease in the HOMA-IR values calculated in repeated measurements in patients with and without DM. Conclusion: In our study, insulin resistance decreased in patients receiving HBO2 therapy. The fact that this decrease was also shown in patients without DM strengthens the idea that this decrease is related to HBO2 therapy. Further research is needed to gain a more comprehensive understanding of the therapeutic potential of HBO2 therapy in managing insulin resistance.